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François Cinotti
- Postdoctoral researcher
- Team: ACIDE
- Email: cinotti@isir.upmc.fr
- Bio: Former PhD student at ISIR (2015–2019), I am a researcher in computational neuroscience and biological systems modelling, with a particular interest in the mechanisms of learning and decision-making. My work focuses on meta-learning, that is, how organisms regulate their learning parameters in order to adapt their learning rate and exploration-exploitation trade-off to their environment. I am currently working on modelling an experiment conducted by a team of neuroscientists in Bordeaux, aimed at understanding how initial learning conditions continue to affect future learning abilities. My research also covers the multiple roles of dopamine in learning and motivation, the development of Bayesian methods to infer neuronal connectivity, and the modelling of foraging behaviour and sign-tracking/goal-tracking phenomena. In parallel, I have developed biophysical models of arterial thrombosis as well as software tools for experimental data analysis using Shiny for R. I am also interested in the theoretical and philosophical implications of the unique feature of mistake-making in living systems.
Publications
- François Cinotti, Etienne Coutureau, Mehdi Khamassi, Alain R Marchand, Benoît Girard. Regulation of reinforcement learning parameters captures long‐term changes in rat behaviour. European Journal of Neuroscience, 2024, ⟨10.1111/ejn.16449⟩. ⟨hal-04630200⟩
- François Cinotti, Etienne Coutureau, Mehdi Khamassi, Alain Marchand, Benoît Girard. Regulation of the exploration-exploitation trade-off captures long-term changes in rat behaviour. European Journal of Neuroscience, 2023, 60 (4), pp.4469-4490. ⟨10.1111/ejn.16449⟩. ⟨hal-04228026⟩
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Neema Moin Afshar, François Cinotti, David A. Martin, Mehdi Khamassi, Donna J Calu, et al.. Reward-mediated, model-free reinforcement-learning mechanisms in Pavlovian and instrumental tasks are related. Journal of Neuroscience, 2022, 43 (3), pp.458-471. ⟨10.1523/JNEUROSCI.1113-22.2022⟩. ⟨hal-03800432⟩
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- François Cinotti, Virginie Fresno, Nassim Aklil, Etienne Coutureau, Benoît Girard, et al.. Dopamine blockade impairs the exploration-exploitation trade-off in rats. Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-43245-z⟩. ⟨hal-02121649⟩
- François Cinotti, Alain Marchand, Matthew R Roesch, Benoît Girard, Mehdi Khamassi. Impacts of inter-trial interval duration on a computational model of sign-tracking vs. goal-tracking behaviour. Psychopharmacology, 2019. ⟨hal-02270920⟩
- François Cinotti. Computational modelling of the variability and regulation of reinforcement learning and the associated dopaminergic signalling in Rats. Cognitive science. Université Sorbonne, 2019. English. ⟨NNT : 2019SORUS096⟩. ⟨tel-04054722⟩
